Hydrogen-enriched water has been shown to lower inflammatory responses in healthy adults through a randomized, double-blind, placebo-controlled trial.

→ The research demonstrated that consistent consumption of hydrogen-rich water significantly reduced inflammation by suppressing NF-κB signaling, a central pathway regulating inflammatory activity. This indicates that hydrogen water boosts the body’s antioxidant capacity, which in turn effectively counteracts inflammation.
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→ Participants who consumed high-concentration hydrogen water experienced clear improvements in multiple health markers. These included reductions in cholesterol and blood glucose levels, as well as a decline in HbA1c, the key indicator of long-term blood sugar regulation. Furthermore, inflammation-related biomarkers and redox balance improved significantly compared to the placebo group. These findings suggest hydrogen water may be a valuable aid in controlling cholesterol, blood sugar, and oxidative stress.
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→ Long-term intake of hydrogen water led to a measurable decrease in markers of oxidative stress and inflammation. Notably, reductions within the central nervous system were associated with relief from negative emotions such as stress and anxiety, along with enhanced autonomic nervous system function. The evidence points toward hydrogen water playing an important role in supporting mental health and overall neurological well-being.
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→ This study observed a significant decrease in Interleukin-6 (IL-6) levels in individuals who consumed hydrogen water, highlighting its strong anti-inflammatory activity. In addition, hydrogen water was shown to help alleviate fatigue related to illness and improve blood coagulation biomarkers. Collectively, these findings emphasize the therapeutic potential of hydrogen water in reducing inflammation, combating fatigue, and supporting circulatory health.
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Hydrogen-enriched water has been shown to lower inflammatory responses in healthy adults through a randomized, double-blind, placebo-controlled trial.

→ Participants who consumed hydrogen water demonstrated notable gains in endurance capacity and a measurable reduction in fatigue. Endurance was assessed through maximal oxygen uptake (VO₂max), while fatigue was evaluated using Borg’s scale. Both outcomes improved significantly compared to the placebo group. Taken together, the results indicate that hydrogen water, when consumed prior to physical exertion, can serve as an effective pre-exercise supplement by both enhancing aerobic performance and reducing fatigue perception.
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→ Findings from this trial support hydrogen water as a practical approach to combating fatigue while promoting broader health improvements. In addition to measurable reductions in fatigue, subjects experienced enhanced cardiorespiratory endurance, improved musculoskeletal performance, and better sleep quality. These outcomes reinforce the role of hydrogen water as a comprehensive intervention for physical and physiological well-being.
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→ This meta-analysis synthesized evidence across multiple trials and confirmed the anti-fatigue benefits of hydrogen supplementation. Results showed statistically significant reductions in the Rating of Perceived Exertion (RPE) and blood lactate accumulation, with pooled effect sizes of -0.38 and -0.42, respectively. Importantly, the relatively low heterogeneity between studies (I² = 33.6% for RPE and 35.6% for lactate) demonstrates that the observed benefits are consistent and reproducible across different populations and experimental designs.
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→ After 28 days of supplementation, women who consumed hydrogen-rich water displayed significant improvements in body composition, metabolic health, and mitochondrial activity. Most notably, their VO₂max increased to 26.2 ± 4.8 ml/kg/min compared to 24.2 ± 4.1 ml/kg/min in the placebo group, reaching statistical significance (P = 0.03). These outcomes confirm that hydrogen water supplementation not only reduces fatigue but also enhances aerobic capacity, making it a promising tool for improving metabolic resilience and exercise performance.
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Hydrogen-rich water has been studied extensively for its effects on body composition, metabolism, and weight regulation.

→ Regular consumption of hydrogen water was associated with significant health improvements. Participants showed reductions in heart rate, body mass index (BMI), waist-to-hip ratio, and blood glucose levels. Markers of inflammation also declined, suggesting that hydrogen water not only aids in weight management but also supports broader metabolic health.
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→ Patients drinking hydrogen water experienced a measurable decrease in liver fat, dropping from 284.0 ± 118.1 mM to 256.5 ± 108.3 mM. Total body fat was reduced by 4.2%, compared to just 0.6% in the placebo group. Liver enzyme profiles also improved, highlighting hydrogen water’s role in promoting both fat loss and liver health.
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→ Over the 24-week period, participants consuming hydrogen water recorded meaningful decreases in BMI and waist circumference (average reduction of 0.7 kg/m²). Glucose levels fell significantly, from 121.5 ± 61.0 to 103.1 ± 33.0, alongside reductions in oxidative stress biomarkers. These outcomes reinforce hydrogen water’s impact on metabolic regulation and fat reduction.
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→ Participants with non-alcoholic fatty liver disease who consumed hydrogen water lost an average of 1.1 kg in body weight and showed decreases in BMI, whereas the placebo group gained weight over the same period. These findings suggest hydrogen water can be an effective adjunct for weight management, particularly in populations at metabolic risk.
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Hydrogen-rich water has been investigated for its potential to protect joints, reduce oxidative stress, and support recovery from injuries.

→ Findings suggest that hydrogen water may serve as a useful complement to conventional therapy for rheumatoid arthritis (RA). Its benefits appear particularly significant in early-stage patients and in those who test negative for anti-citrullinated protein antibodies (ACPA). By lowering oxidative stress, hydrogen water could play an important role in treatment strategies and in guiding clinical decision-making for RA management.
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→ This pilot trial showed that hydrogen-rich water was just as effective as the widely used RICE protocol (Rest, Ice, Compression, Elevation) for managing acute ankle sprains. Participants consuming hydrogen water experienced reduced swelling, better range of motion, and improved single-leg balance. These results indicate hydrogen water may be a practical alternative for restoring healthy joint structure and function after injury.
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→ Individuals who received hydrogen-based therapy recovered joint flexibility more quickly than controls. Both flexion and extension improved significantly, suggesting that oral and topical hydrogen treatments can accelerate rehabilitation and enhance mobility after joint or soft tissue injury.
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→ This case report documented notable improvements in pain, swelling, and joint range of motion following hydrogen-rich hydrotherapy for an ankle sprain. These outcomes highlight the potential for hydrogen water to support faster recovery and assist in the restoration of joint function in acute sports-related injuries.
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Hydrogen therapy has been shown to support cognitive performance, reduce anxiety, and protect neurological health through its antioxidant and anti-inflammatory properties.

→ Subjects who received hydrogen treatment demonstrated notable improvements in cognitive function and reductions in anxiety compared to the control group. Tissue analysis using hematoxylin and eosin staining also showed fewer pyknotic cells — which are typically linked to cellular death and tissue damage. These findings suggest that hydrogen provides neuroprotective benefits, safeguarding brain cells and supporting overall cognitive health.
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→ A single dose of hydrogen-rich water significantly enhanced mental performance in young adults experiencing sleep deprivation. Participants consuming hydrogen water completed trial-making tests faster than those given a control beverage. This research highlights hydrogen water’s potential as a safe, effective strategy to boost alertness and cognitive function when under stress or fatigue.
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→ Patients who received hydrogen gas therapy exhibited faster and greater improvements in National Institutes of Health Stroke Scale (NIHSS) scores compared to individuals receiving standard therapy alone. Additionally, MRI scans showed favorable changes in signal intensity, pointing to potential neuroprotective effects. These results suggest hydrogen could serve as a promising adjunct therapy to enhance recovery outcomes in stroke patients.
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Hydrogen-rich water has been studied for its ability to improve mood, reduce anxiety, and regulate the autonomic nervous system in daily life.

→ In this trial, adults who consumed hydrogen-rich water for a period of four weeks experienced meaningful improvements in overall quality of life. Participants reported better mood stability and reduced levels of anxiety. Physiological measures showed a decrease in resting sympathetic nervous system activity, which is often associated with stress responses. These findings suggest that regular intake of hydrogen water may help support emotional well-being and promote healthier stress regulation by balancing nervous system function.
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Hydrogen water has been investigated for its ability to slow cellular and physiological processes associated with aging, as well as for its potential to protect against age-related diseases.

→ Intake of hydrogen water was associated with beneficial effects on markers of biological aging in healthy elderly individuals. Researchers observed an extension of mean telomere length — a critical indicator of cellular aging — as well as a trend toward improved DNA methylation, which plays a vital role in gene regulation and age-related processes. These findings suggest hydrogen water may support healthier cellular aging.
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→ Over a six-month period, older adults consuming hydrogen water demonstrated positive changes in several aging biomarkers. Improvements were noted in telomere preservation and cellular functionality, both of which are typically compromised with age. These results support hydrogen water’s potential as an anti-aging intervention contributing to longevity and improved healthspan.
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→ Molecular hydrogen combats age-related decline primarily through its antioxidative and anti-inflammatory mechanisms. Researchers concluded that hydrogen therapy could be an effective approach in managing or preventing a wide spectrum of age-related diseases. Furthermore, H₂-based interventions may represent an innovative strategy to enhance healthy longevity and overall quality of life.
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→ In an animal model, mice fed a high-fat diet (HFD) and given hydrogen water showed a marked reduction in endothelial cells within atheromas that expressed senescence markers such as p16INK4a and p21, compared to controls. This indicates that hydrogen water may exert a suppressive effect on vascular aging, helping slow the progression of structural and functional vascular decline associated with aging.
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Hydrogen plays a key role in digestive health, gut microbiota balance, and metabolic function, with recent studies highlighting the potential of hydrogen-rich water to positively influence gastrointestinal well-being.

→ Among the roughly 100 trillion bacteria inhabiting the human gut, about 70% are capable of producing hydrogen. These microorganisms contain hydrogenase, an enzyme that facilitates hydrogen metabolism. They also metabolize carbohydrates to generate short-chain fatty acids such as acetic acid and butyric acid, both essential for gut and metabolic health. This underscores the importance of hydrogen in maintaining digestive function and microbial balance.
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→ Participants consuming hydrogen-rich water for 12 weeks displayed significantly elevated levels of Ghrelin, a peptide hormone produced in the stomach that regulates appetite, digestion, and gut function. Increased Ghrelin suggests that hydrogen water may stimulate digestive processes and improve gastrointestinal health.
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→ After 12 weeks of hydrogen water supplementation, participants exhibited significant increases in fecal short-chain fatty acids (SCFAs): acetic acid (+2.10 mg/g), propionic acid (+2.44 mg), and butyric acid (+2.98 mg). SCFAs are vital for intestinal health, strengthening the gut barrier, enhancing mucus production, and offering protection against inflammation. These findings confirm hydrogen water’s role in fostering a healthier gut environment.
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→ Analysis showed that hydrogen water consumption significantly influenced starch and sucrose metabolism and led to meaningful shifts in gut microbiota composition. These structural changes in microbial communities suggest that hydrogen water can modulate carbohydrate processing and promote healthier microbial dynamics within the gut.
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Hydrogen-rich water has been studied for its role in enhancing endurance, improving cardiorespiratory fitness, and reducing markers of fatigue during physical activity.

→ Participants who consumed hydrogen water experienced measurable improvements in both endurance and fatigue compared to the placebo group. Endurance gains were demonstrated through higher maximal oxygen uptake (VO₂max), while fatigue reduction was confirmed using Borg’s scale. These findings suggest hydrogen water may function as an effective pre-exercise supplement, enhancing aerobic performance and reducing exertion-related fatigue.
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→ Over four weeks, women supplementing with hydrogen water exhibited significant improvements in body composition, mitochondrial function, and metabolic profiles. Their VO₂max increased to 26.2 ± 4.8 ml/kg/min compared to 24.2 ± 4.1 ml/kg/min in the placebo group, with results reaching statistical significance (P = 0.03). These findings highlight hydrogen water’s potential to improve overall physical performance and support healthier metabolic function.
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→ This investigation recorded reductions in heart rate and respiratory rate during exercise among participants consuming hydrogen water. Heart rate decreased from 125.9 ± 25.5 to 120.8 ± 25.7, while respiratory efficiency improved. Together, these changes suggest that hydrogen supplementation can enhance cardiovascular efficiency during physical exertion.
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→ A meta-analysis provided moderate evidence that hydrogen supplementation reduces fatigue and improves aerobic markers. Across multiple studies, decreases were seen in both Rating of Perceived Exertion (RPE) (SMDpooled = -0.38) and blood lactate accumulation (SMDpooled = -0.42). Importantly, heterogeneity was low (I² = 33.6% for RPE and 35.6% for lactate), reinforcing the consistency and reproducibility of hydrogen’s anti-fatigue benefits.
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